The Morning Dose #99: Telmisartan, PRL-8-53, Fat Loss and Cutting Cycles

In this week’s edition of The Morning Dose:

Telmisartan and Hair Loss: Myth or Reality?

PRL-8-53: Nootropic for Memory and Mental Clarity

The 5 Best SARMs for Fat Loss and Cutting Cycles

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Telmisartan and Hair Loss: Myth or Reality?

Photo by Alora Griffiths on Unsplash

Telmisartan, a well-studied angiotensin II receptor blocker (ARB), has recently entered the spotlight for its potential role in hair loss research. This 2025 review explores whether this blood pressure medication has any credible impact on hair health and regeneration.

What’s Covered:

 Mechanisms of Action
Research investigates Telmisartan’s possible influence on hair follicles through its anti-inflammatory, antifibrotic, and PPAR-γ agonist properties. These pathways may theoretically support scalp circulation and reduce follicular miniaturization.

Hair Growth & Shedding
While primarily used for hypertension and metabolic regulation, emerging studies examine Telmisartan’s effects on hair density, shedding cycles, and scalp environment. Early findings remain limited and mixed, but promising leads are being explored.

Research vs. Reality
Despite anecdotal reports, clinical evidence is still developing. Experts stress that more controlled trials are needed to determine any causative link between Telmisartan and improved hair outcomes.

Curious whether Telmisartan is myth or reality when it comes to hair loss?
Click here to read the full guide on Muscle and Brawn

PRL-8-53: Nootropic for Memory and Mental Clarity

Photo by Rohit Reddy on Unsplash

PRL-8-53 continues to draw attention in nootropic research as a potential memory-enhancing compound with rapid onset and short duration of action. In 2025, studies further examine its mechanisms and use in memory consolidation and verbal recall.

What’s Covered:

Mechanisms of Action
PRL-8-53 is believed to modulate acetylcholine and dopamine pathways while enhancing synaptic plasticity. Its effect on neurotransmitter release may explain the observed improvements in cognitive performance and memory retention.

 Research Highlights
Initial human trials have shown notable increases in short-term memory and verbal learning after single doses, with few adverse effects reported. Researchers continue exploring its use in memory studies and cognitive fatigue models.

 Experimental Use & Results
While not approved for clinical use, PRL-8-53 remains under investigation in research settings. Observed benefits include improved word recall, sharper focus, and potential application in age-related cognitive decline models.

Curious how PRL-8-53 compares to other nootropics for memory support?
Click here to read the full guide on Muscle and Brawn

The 5 Best SARMs for Fat Loss and Cutting Cycles

Photo by John Arano on Unsplash

Selective Androgen Receptor Modulators (SARMs) are widely studied for their role in muscle preservation and fat metabolism—especially during cutting phases. In 2025, research continues to investigate which SARMs are most effective in promoting lean mass while supporting fat loss.

What’s Covered:

 Mechanisms of Action
SARMs bind to androgen receptors in muscle and bone tissue, triggering anabolic activity without the same androgenic effects seen with traditional compounds. This makes them a promising focus for studies targeting fat oxidation and muscle retention.

 Best SARMs for Fat Reduction
Top SARMs explored for cutting include Cardarine (GW-501516), Stenabolic (SR9009), Andarine (S4), Ostarine (MK-2866), and RAD-140. Each offers unique pathways—ranging from increased endurance to enhanced glucose metabolism and body recomposition.

 Research Applications & Dosing
Experimental protocols assess the effects of SARMs on fat mass reduction, energy output, and metabolic rate. Dosage studies vary, with ongoing research into safety, optimal cycles, and stacked combinations for maximized results.

Curious which SARMs are leading the research in fat loss performance for 2025?
Click here to read the full guide on Muscle and Brawn